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๐ŸŽ—๏ธ Cancer & Oncology

New cancer drugs, new trials and the hottest cancer research.

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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyFecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

Most-Cited Cancer Immunotherapy Papers This Year

Citations of papers published this year
2Thymic health and immunotherapy outcomes in patients with cancerโ€ข
3Microbiota-induced T cell plasticity enables immune-mediated tumour controlโ€ข
4Lactylation stabilizes PD-L1 to promote tumor immune evasion and cell growthโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyCilta-cel in lenalidomide-refractory multiple myeloma (CARTITUDE-4): an updated analysis including overall survival from an open-label, multicentre, randomised, phase 3 trial

Most-Cited CAR-T Cell Therapy Papers This Year

Citations of papers published this year
2In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 studyโ€ข
3In vivo site-specific engineering to reprogram T cellsโ€ข
4Critical role for a high-plasticity cell state in lung cancerโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyDual-Targeting mRNA Cancer Vaccines for Simultaneous Antigen Presentation in Dendritic and Tumor Cells

Most-Cited Cancer Vaccines Papers This Year

Citations of papers published this year
2Engineering the future of precision cancer immunotherapy: Integrating neoantigen biology, engineered delivery platforms, and clinical translation.โ€ข
3Enhanced efficacy of a next-generation EEEV self-replicating RNA platform for combination cancer immunotherapiesโ€ข
4Synthetic DNA vaccine platform elicits potent immunity where electroporated naked-mRNA is non-immunogenicโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyPerioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer

Most-Cited Antibody-Drug Conjugates Papers This Year

Citations of papers published this year
2HS-20093, a B7-H3-targeted antibody-drug conjugate in lung cancer: Results from the ARTEMIS-001 phase 1a/b trialโ€ข
3Payload Diversification Overcomes Resistance and Guides Sequential Antibodyโ€“Drug Conjugate Therapy in Breast Cancerโ€ข
4Sacituzumab tirumotecan plus pembrolizumab versus pembrolizumab in PD-L1-positive advanced non-small-cell lung cancer (OptiTROP-Lung05): interim analysis of a randomised, open-label, phase 3 trialโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyHarmonizing fusion modeling for accurate liver cancer diagnosis using explainable artificial intelligence: a step toward trustworthy medical AI

Most-Cited AI in Cancer Detection Papers This Year

Citations of papers published this year
2Explainable Artificial Intelligence-Driven Salivary Exosome Spectroscopic Profiling for Clinical Diagnosis and Metastasis Detection of Oral Cancerโ€ข
3AI-Integrated biosensors: A paradigm shift in multi-cancer detection with enhanced sensitivity and specificityโ€ข
4Deep visual detection system for oral squamous cell carcinomaโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyETCAMAH

Newly Approved Cancer Drugs (FDA)

Original applications approved in the last 12 months
2ZENBEXUSโ€ข
3JIDEYTROโ€ข
4ZYOGREENโ€ข
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๐Ÿ† #1 ยท ๐ŸŽ—๏ธ Cancer & OncologyA Clinical Trial of Gocatamig (MK-6070) With Durvalumab in Participants With Small Cell Lung Cancer (MK-6070-004)

Newest Phase 3 Cancer Drug Trials

Recruiting or about to recruit
2Study of CM336+CM313 Combination Therapy in Patients With Relapsed or Refractory Multiple Myeloma
3TRINITY TRIAL; Trial Of PRRT Plus CAPTEM Vs CAPTEM Alone In Well Differentiated GEP NETS
4A Study to Evaluate Surovatamig Combined With R-CHOP in Participants of 18 to < 80 Years of Age With Previously Untreated Large B-cell Lymphoma With IPI Score 2 to 5
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